Optimized Response-Adaptive Clinical Trials (eBook, PDF)
Sequential Treatment Allocation Based on Markov Decision Problems
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Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.ContentsIntroduction to Markov Decision Problems and ExamplesFinite and Infinite Horizo...
Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.
Contents
Target Groups
The Author
Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
Contents
- Introduction to Markov Decision Problems and Examples
- Finite and Infinite Horizon Markov Decision Problems
- Solution Algorithms: Backward Induction, Value Iteration and Policy Iteration
- Designing Response Adaptive Clinical Trials with Markov Decision Problems
Target Groups
- Researchers and students in the fields of mathematics and statistics
- Professionals in the pharmaceutical industry<
The Author
Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.
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