Next-Generation In Vitro DMPK Models: From Static Cell Lines to Dynamic Organoids and Organ-on-Chip Systems (eBook, ePUB)
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As the pharmaceutical industry accelerates its shift toward precision medicine, the demand for more predictive, human-relevant models in drug metabolism and pharmacokinetics (DMPK) has never been greater. Next-Generation In Vitro Models in DMPK explores the paradigm shift from traditional static assays to dynamic, microengineered systems like organoids, organ-on-chip platforms, and integrated multi-organ models.Bridging in silico modeling, high-resolution bioanalytical technologies, and regulatory science, this book offers a comprehensive guide for scientists, engineers, and regulatory profess...
As the pharmaceutical industry accelerates its shift toward precision medicine, the demand for more predictive, human-relevant models in drug metabolism and pharmacokinetics (DMPK) has never been greater. Next-Generation In Vitro Models in DMPK explores the paradigm shift from traditional static assays to dynamic, microengineered systems like organoids, organ-on-chip platforms, and integrated multi-organ models.
Bridging in silico modeling, high-resolution bioanalytical technologies, and regulatory science, this book offers a comprehensive guide for scientists, engineers, and regulatory professionals seeking to improve preclinical prediction of human pharmacokinetics, toxicity, and efficacy. With contributions from academia, industry, and global regulatory bodies, it presents a roadmap to the future of drug discoverywhere patient-on-chip models may soon become the gold standard.
Bridging in silico modeling, high-resolution bioanalytical technologies, and regulatory science, this book offers a comprehensive guide for scientists, engineers, and regulatory professionals seeking to improve preclinical prediction of human pharmacokinetics, toxicity, and efficacy. With contributions from academia, industry, and global regulatory bodies, it presents a roadmap to the future of drug discoverywhere patient-on-chip models may soon become the gold standard.
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