Myelofibrosis, (Bone Marrow Fibrosis) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions (eBook, ePUB)
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>3 (on 0-4 scale). 2.A2: pathogenetic mutation (e.g., in JAK2 or MPL), or absence of both BCR-ABL1 and reactive causes of bone marrow fibrosis. a.B1: palpable splenomegaly. b.B2: unexplained anemia. c.B3: leuko-erythroblastosis. d.B4: tear-drop red cells. e.B5: constitutional symptoms: drenching night sweats, weight loss >10% over six months, unexplained fever (>37.5°C) or diffuse bone pains. f.B6: histological evidence of extra-medullary hematopoiesis. Treatment Bone marrow or stem cell transplant may reduce symptoms, and may even cure the disease Other treatment may be: 1.Blood transfusions...
>3 (on 0-4 scale). 2.A2: pathogenetic mutation (e.g., in JAK2 or MPL), or absence of both BCR-ABL1 and reactive causes of bone marrow fibrosis. a.B1: palpable splenomegaly. b.B2: unexplained anemia. c.B3: leuko-erythroblastosis. d.B4: tear-drop red cells. e.B5: constitutional symptoms: drenching night sweats, weight loss >10% over six months, unexplained fever (>37.5°C) or diffuse bone pains. f.B6: histological evidence of extra-medullary hematopoiesis. Treatment Bone marrow or stem cell transplant may reduce symptoms, and may even cure the disease Other treatment may be: 1.Blood transfusions and medicines to correct anemia 2.Radiation and chemotherapy 3.Medicines to target a genetic mutation 4.Removal of the spleen if swelling causes symptoms, or to help with anemia Allogeneic stem cell transplantation (SCT) is the only treatment modality with curative possibility for the bone marrow Asymptomatic low-danger patients may be seen without intervention Patients with hemolysis should take folic acid supplements. Allopurinol should be taken for hyper-uricemia. Hydroxyurea has conventionally been the favored and most often used agent effective at improving splenomegaly, leukocytosis and thrombocytosis Interferon alfa and other drug treatments such as Interleukin 10 have shown some benefit JAK inhibitors (e.g., ruxolitinib) have recently proven successful in the treatment. Mild cases may need only supportive treatment. Higher-risk disease may respond to ruxolitinib. Allogeneic SCT may cure. TABLE OF CONTENT Introductio...
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