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Immune and intrinsic correlates of protection in Rhesus macaques immunised against Simian Immunodeficiency Virus (eBook, PDF)

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Efficacy assessment of AIDS vaccines relies both on pre-clinically challenging immunised monkeys with a pathogenic virus and subsequent monitoring of infection rates in large human trials. Conventional parameters of vaccine-induced immune responses do not completely predict outcome. Moreover, existing methods for testing cellular immunity are sophisticated and difficult to establish in resource-limited settings, thereby constraining large studies. There is a need for study models that bridge the gap between preclinical and clinical vaccine testing, and which are able to predict a virus-specifi...

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