Hematopoietic Stem Cells (eBook, PDF)

This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell stud...

Weiterlesen / Aufklappen

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Geräte: PC
ohne Kopierschutz
eBook Hilfe
Größe: 7.27MB

Barrierefreiheit

Text-to-Speech
E-Mail des Verlags für Barrierefreiheitsfragen: accessibilitysupport@springernature.com
Alle Inhalte über Screenreader oder taktile Geräte zugänglich
Navigation über vor-/zurück-Elemente ohne Inhaltsverzeichnis
Hoher Kontrast zwischen Text und Hintergrund (min. 4.5 =>1)
Inhalte verständlich ohne Farbwahrnehmung
Kurze Alternativtexte für nicht-textuelle Inhalte vorhanden
Text und Medien in logischer Lesereihenfolge angeordnet
Navigierbares Inhaltsverzeichnis für direkten Zugriff auf Text und Medien
Keine Einschränkung der Vorlesefunktionen, außer bei spezifischen Ausnahmen

Dr. Meng Zhao, a distinguished stem cell biologist and hematologist, is currently serving as a professor at the Zhongshan School of Medicine, Sun Yat-sen University. His research primarily focuses on unraveling the intricate mechanisms governing blood stem cells and developing therapeutic strategies for hematopoietic stem cell transplantation and leukemia treatment. In his laboratory, Dr. Zhao utilizes genetic models and clinical specimens to investigate both the intrinsic cellular control and microenvironmental influence on normal and leukemic stem cells. Noteworthy contributions from Dr. Zhao include identifying megakaryocytes as a hematopoietic stem cell niche, characterizing leukemic stem cells in T-cell acute lymphoblastic leukemia, and discovering amino acid catabolism within hematopoietic stem cells. The primary objective of Dr. Zhao's laboratory is to gain comprehensive insights into the complex metabolic intricacies that govern both normal and leukemic stem cells within the dynamic bone marrow microenvironment. Prof. Pengxu Qian obtained his bachelor degree in 2006, and his Ph.D. degree in 2012 from University of Science and Technology of China (USTC). During his postdoctoral training in Prof. Linheng Li's lab at Stowers Institute for Medical Research from 2012 to 2017, Dr. Qian was funded by the American Society of Hematology (ASH) Scholar Award to study the roles of DNA methylation and imprinting genes in hematopoietic stem cells. In Nov 2017, Dr. Qian started his lab as principal investigator in Zhejiang University School of Medicine, to study the roles and mechanisms of epigenetic regulators in normal hematopoiesis and leukemogenesis. The major contributions from Dr. Qian include illustrating the roles and mechanisms of the Dlk1-Gtl2 imprinting locus, the differentially methylated region (DMR) DERARE in the Hoxb cluster, and the m6A reader YTHDF2 in normal hematopoiesis and leukemogenesis. The primary objectives of Dr. Qian's laboratory are to decipher the epigenetic regulatory mechanisms underlying HSC homeostasis and leukemogenesis and to develop novel therapeutic approaches against hematopoietic malignancies.

Produktdetails