eBook, ePUB

Epigenetics of Aging and Longevity (eBook, ePUB)

Translational Epigenetics vol 4

Redaktion: Moskalev, Alexey; Vaiserman, Alexander

Beschreibung

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses-including cancer and cardiovascular, metabolic, and neurodegenerative diseases-are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. - Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease - Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory - Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Technische Details

• Geräte: eReader
• ohne Kopierschutz

Barrierefreiheit

• Text-to-Speech
• E-Mail des Verlags für Barrierefreiheitsfragen: [e-mail]
• E-Mail eines vertrauenswürdigen Mittlers für Barrierefreiheitsfragen: [e-mail]
• Seitennummerierung folgt dem gedruckten Werk
• Mathematische Inhalte in MathML für assistive Technologien
• Text und Medien in logischer Lesereihenfolge angeordnet
• Navigierbarer Index mit direktem Zugriff auf Indexbegriffe
• Navigierbares Inhaltsverzeichnis für direkten Zugriff auf Text und Medien
• Keine Einschränkung der Vorlesefunktionen, außer bei spezifischen Ausnahmen

Autor

Dr. Vaiserman is head of the Laboratory of Epigenetics at the Institute of Gerontology, where his research has focused on long-term health consequences of adverse conditions in early life, genetic and epigenetic mechanisms of age-associated diseases, telomere length in patients with age-related chronic diseases, and molecular mechanisms mediating lifespan in Drosophila. He earned his PhD from the Institute of Gerontology, Kiev, Ukraine in 2004. During the last 7 years, Dr. Vaiserman was Project Leader for several Ukrainian government sponsored research projects. Dr. Vaiserman is also a member of the editorial boards of the journals Biogerontology, Frontiers in Genetics of Aging, and Gerontology & Geriatric Research. To-date, he has published four book chapters, as well as 65 papers in peer reviewed journals.

Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 544
• Erscheinungstermin: 17. November 2017
• Englisch
• ISBN-13: 9780128110836
• Artikelnr.: 50214879