eBook, ePUB

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy (eBook, ePUB)

Beschreibung

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. - Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner - Describes the involvement of efflux pumps in cancer resistance in different cancer types - Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

Technische Details

• Geräte: eReader
• ohne Kopierschutz

Barrierefreiheit

• Text-to-Speech
• E-Mail des Verlags für Barrierefreiheitsfragen: [e-mail]
• E-Mail eines vertrauenswürdigen Mittlers für Barrierefreiheitsfragen: [e-mail]
• Seitennummerierung folgt dem gedruckten Werk
• Mathematische Inhalte in MathML für assistive Technologien
• Text und Medien in logischer Lesereihenfolge angeordnet
• Navigierbarer Index mit direktem Zugriff auf Indexbegriffe
• Navigierbares Inhaltsverzeichnis für direkten Zugriff auf Text und Medien
• Keine Einschränkung der Vorlesefunktionen, außer bei spezifischen Ausnahmen

Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 394
• Erscheinungstermin: 7. November 2019
• Englisch
• ISBN-13: 9780128141410
• Artikelnr.: 61688004

Rezensionen

"The therapeutic success of antineoplastic drugs is a challenge due to the development of chemoresistance by the cancer cells. An understanding of the mechanism of chemoresistance and chemo-sensitization is critical to improving cancer treatment outcomes. Contributed by many experts around the world, this book offers up-to-date information on the efflux transporters and possible strategies to inhibit the efflux pumps in cancer cells. There are several books in the marketplace related to chemoresistance and chemo-sensitization. This book, however, focuses on the mechanistic approach to characterization and inhibition of efflux transporters. Thus, it is expected to be well received by the scientists working in this field of study." --Doody