eBook, PDF

Biophysics of the Failing Heart (eBook, PDF)

Physics and Biology of Heart Muscle

Redaktion: Solaro, R. John; Tardiff, Jil C.

Beschreibung

Biophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels.

Technische Details

• Geräte: PC
• ohne Kopierschutz
• Größe: 4.34MB

Barrierefreiheit

• Text-to-Speech

Autor

R. John Solaro is a Distinguished University Professor at the University of Illinois, Chicago and the head of the Physiology and Biophysics department. Jil C. Tardiff is a Professor at the Department of Cellular and Molecular Medicine at the University of Arizona in Tucson. She is also a practicing cardiologist.

Produktdetails

• Verlag: Springer New York
• Seitenzahl: 253
• Erscheinungstermin: 13. August 2013
• Englisch
• ISBN-13: 9781461476788
• Artikelnr.: 43802723

Rezensionen

From the reviews:

"This is an up-to-date synthesis of the molecular and cellular biophysics of both normal and various cardiac pathologies with an emphasis on heart failure. ... It is designed as a useful resource for cardiology practitioners and basic scientists looking for a current in-depth review of cardiac molecular biophysiology. ... The book is extensively illustrated with diagrams and figures. This is a necessary addition to the literature addressing the biophysiology in the failing heart. It will be useful to cardiovascular specialists and basic scientists." (Don A. Davis, Doody's Book Reviews, January, 2014)