BetaSys (eBook, PDF)
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Redaktion: Booß-Bavnbek, Bernhelm; Renström, Erik; Pociot, Flemming; Larsen, Jesper; Klösgen, Beate
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The insulin secreting ß-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ß-cell function; and at the challenge to formulate a comprehensive and robust model of the main ne...
The insulin secreting ß-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the ß-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.
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