Artificial Assemblies with Cooperative DNA Recognition (eBook, PDF)
Zutao Yu
eBook, PDF

Artificial Assemblies with Cooperative DNA Recognition (eBook, PDF)

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This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole-imidazole polyamides (PIPs).PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerou...

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