Yadernaq medicina i wizualizaciq mozga
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Optimizirowannyj protokol ätoj knigi naprawlen na izuchenie i nakoplenie nowyh radioteraktorow, kotorye ispol'zowalis' dlq wizualizacii mozga w oblasti qdernoj mediciny, takih kak [99mTc]gistamin, [99mTc]ropinirol , [99mTc] (Sn) oxiracetam, [99mTc] biohin HMPAO [ 99mTc]BH , [99mTc ](Na2S2O4) oxiracetam, [99mTc] N (BDTC)2 , [99mTc]N (PDTC)2 , [99mTc] N (EOEDTC)2, [99mTc] N-piracetam , [99mTc] N-gistamin , [99mTc] (CO)3 DEDT , [99mTc] (CO)3-5HTIDA , [99mTc] (CO)3-OH-PP-CS2, [99mTc] (CO)3 oxiracetam, [125I] sibutramin, [125I] jodofluoxetin, [99mTc] fenobarbital, [125I] trazodon i [125I] galoperi...
Optimizirowannyj protokol ätoj knigi naprawlen na izuchenie i nakoplenie nowyh radioteraktorow, kotorye ispol'zowalis' dlq wizualizacii mozga w oblasti qdernoj mediciny, takih kak [99mTc]gistamin, [99mTc]ropinirol , [99mTc] (Sn) oxiracetam, [99mTc] biohin HMPAO [ 99mTc]BH , [99mTc ](Na2S2O4) oxiracetam, [99mTc] N (BDTC)2 , [99mTc]N (PDTC)2 , [99mTc] N (EOEDTC)2, [99mTc] N-piracetam , [99mTc] N-gistamin , [99mTc] (CO)3 DEDT , [99mTc] (CO)3-5HTIDA , [99mTc] (CO)3-OH-PP-CS2, [99mTc] (CO)3 oxiracetam, [125I] sibutramin, [125I] jodofluoxetin, [99mTc] fenobarbital, [125I] trazodon i [125I] galoperidol. Oni byli pomecheny [125I] ili [99mTc]. Dlq optimizacii processa mecheniq byli sistematicheski izucheny takie faktory, kak kolichestwo okislitelq i wosstanowitelq, kolichestwo substrata, pH, temperatura reakcii i wremq reakcii. Mechenoe soedinenie bylo wydeleno i ochischeno s pomosch'ü tonkoslojnoj hromatografii (TSH), bumazhnogo älektroforeza i wysokoäffektiwnoj zhidkostnoj hromatografii (VJeZhH). Issledowaniq bioraspredeleniq pokazali, chto komplex [99mTc]piracetama obladaet wysokoj stepen'ü pogloscheniq mozgom - 13,5 ± 0,12 % ID/organa cherez 5 minut posle in#ekcii. Jeto luchshe, chem u nedawno otkrytyh agentow.
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