Use of Natural Polysaccharides in Medical Textile Applications
Polysaccharides and its Medical Applications
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Polysaccharides are composed of many monosaccharide units that are joined one to the other by an acetal linkage to give a long chain. In this work two special polysaccharides have been used as candidates in medical textile applications: chitosan and ß-cyclodextrin. Chitosan has been used as a new finishing agent in medical textile application. Chitosan has been used also as antimicrobial coating agent in modern dentistry to treat denture stomatitis. ß-cyclodextrin (ß-CD) has been used in this thesis as a drug release candidate in pharmaceutical application. The very low aqueous solubility o...
Polysaccharides are composed of many monosaccharide units that are joined one to the other by an acetal linkage to give a long chain. In this work two special polysaccharides have been used as candidates in medical textile applications: chitosan and ß-cyclodextrin. Chitosan has been used as a new finishing agent in medical textile application. Chitosan has been used also as antimicrobial coating agent in modern dentistry to treat denture stomatitis. ß-cyclodextrin (ß-CD) has been used in this thesis as a drug release candidate in pharmaceutical application. The very low aqueous solubility of both antifungal agents (econazole nitrate and ciclopirox olamine) does not allow the preparation of a concentrated stock solution. Therefore, complexation with ß-CD has been improved the aqueous solubilities of both drugs without modification of their original structures,and hence increase their bioavailability. The antimycotic influence of ß-cyclodextrin complexes against Candida albicans DSM 11225 and Candida krusei ATCC 6258, hence, the drug solubility has been measured using a new, rapid and novel method called laser nephelometry in microtiter plates.
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