Use of Clean Chemical Technologies in the Synthesis of Drug Molecules
Mark Gronnow
Broschiertes Buch

Use of Clean Chemical Technologies in the Synthesis of Drug Molecules

Supported Palladium Catalysts, Microwave reactors and Clean Synthetic Routes for the Synthesis of Drug Molecules

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The aim of this work was to apply green chemistry techniques and principles, to the synthesis of typical pharmaceutical intermediates and to bridge the gap between academia and industry. Two synthetic routes have been the focus for study; synthesis of the drug, salbutamol and secondly a generic synthesis which combines many typical reactions important to the pharmaceutical industry, such as a Suzuki coupling, reduction, bromination and alkylation. These reactions provide opportunities to demonstrate clean alternatives to transformations of complex molecules which are regularly carried out by t...