Uncoupling proteins,the interface between bioenergetics and metabolism
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The chemiosmotic theory of Peter Mitchell posits that the intermediate between the energy-releasing redox enzymes and the energy-consuming phosphorylation system is the membrane potential generated by proton pumping by three of the redox enzymatic complexes. This requires a tight control of the permeability of the inner membrane, and increasing ionic leaks in the inner membrane lead to uncoupling.
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