Yunjiao Zhang

Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals

• Broschiertes Buch

Produktbeschreibung

This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.

Produktdetails

• Springer Theses
• Verlag: Springer / Springer Nature Singapore / Springer, Berlin
• Artikelnr. des Verlages: 978-981-16-8168-4
• 1st ed. 2022
• Seitenzahl: 172
• Erscheinungstermin: 10. Januar 2023
• Englisch
• Abmessung: 235mm x 155mm x 10mm
• Gewicht: 271g
• ISBN-13: 9789811681684
• ISBN-10: 9811681686
• Artikelnr.: 66918501

Autorenporträt

Inhaltsangabe

Introduction.- Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials.- RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN).- Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating.- RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo.- Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.