Transcriptional Control of Cell Growth
Broschiertes Buch

Transcriptional Control of Cell Growth

The E2F Gene Family

Herausgegeben von Farnham, Peggy J.
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It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor mally control this decision can lead to cancer, cell death, or loss of differentiated...