Total Synthesis of Solifenacin, Sitagliptin and novel methodologies
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Chiral amines are present in peptides, proteins and many natural products, and they are prevalent in drugs. For these reasons, the development of methods for the synthesis of enantiomerically pure compounds that contain amine functionality has featured prominently in organic synthesis.Many researchers from around the world have contributed innovative and often practicall methods using tert-butanesulfinamide as an extremely versatile reagent for the robust and general asymmetric synthesis of diverse classes of amine-containing compounds. The ready availability of tert butanesulfinamide in large...
Chiral amines are present in peptides, proteins and many natural products, and they are prevalent in drugs. For these reasons, the development of methods for the synthesis of enantiomerically pure compounds that contain amine functionality has featured prominently in organic synthesis.Many researchers from around the world have contributed innovative and often practicall methods using tert-butanesulfinamide as an extremely versatile reagent for the robust and general asymmetric synthesis of diverse classes of amine-containing compounds. The ready availability of tert butanesulfinamide in large quantities at low cost, the robustness and generality of many of its methods, and the prominence of amine-containing compounds in drugs, agrochemicals, and naturally occurring materials ensures that tertbutanesulfinamide- based methods will continue to be some of the most extensively used methods in the synthesis.
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