Total Syntheses of Sansalvamide A, Cherimolapeptide C, E, & Analogues

Total Syntheses of Sansalvamide A, Cherimolapeptide C, E, & Analogues

The use of Safety-catch linker for SPPS and KB & MDA-MB-231 cell lines for Anticancer activity

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Cherimolacyclopeptides are a class of cytotoxic cyclic peptides which exhibited significant activities against the human nasopharyngeal carcinoma cell culture system. The synthesis and study of cyclic peptide analogues presents a powerful move in the design and discovery of novel peptide drugs. Thus, the solid-phase syntheses of cherimolacyclopeptide E, cherimolacyclopeptide C, sansalvamide A, and the alanine-substituted analogues of cherimolacyclopeptide E were carried out in the present study. The synthetic cyclic peptides were then subjected to KB and MDA-MB-231 cell lines to examine the ef...