Gebundenes Buch

Therapeutic Strategies to Overcome Alk Resistance in Cancer

Volume 13

Herausgegeben: Friboulet, Luc

Beschreibung

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field.

This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

Autor

Luc Friboulet, PhD, is ERC Principal Investigator and INSERM team leader at Gustave Roussy cancer campus. He studies the tumor adaptation to kinase inhibitors. Linked to a clinical trial named MATCH-R allowing collection of repeated biopsies in patients treated with ALK, ROS1, RET, EGFR, BRAF, FGFR inhibitors Dr. Friboulet characterizes the resistance mechanisms and establishes new laboratory models.

Produktdetails

• Cancer Sensitizing Agents for Chemotherapy Volume 13
• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2019-0-03295-5
• Seitenzahl: 216
• Erscheinungstermin: 14. Januar 2021
• Englisch
• Abmessung: 236mm x 193mm x 18mm
• Gewicht: 630g
• ISBN-13: 9780128217740
• ISBN-10: 012821774X
• Artikelnr.: 60012252

Rezensionen

"This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment." --Anticancer Research