The Role of CVAK104 in Clathrin-Dependent Cellular Pathways
Michael Düwel
Broschiertes Buch

The Role of CVAK104 in Clathrin-Dependent Cellular Pathways

While Kinase May Be its Name, Phosphorylation May Not Be its Game

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Clathrin-coated vesicles (CCVs) are involved in fundamental intracellular transport pathways such as receptor-mediated endocytosis at the plasma membrane and the sorting of lysosomal enzymes at the trans-Golgi network (TGN). The formation of CCVs is a dynamic and complex process that is mediated and controlled by the coat protein clathrin and a battery of accessory proteins.Here I introduce a novel CCV-associated protein with a serine/threonine kinase homology domain, called CVAK104 (Coated-Vesicle-Associated-Kinase of 104 kDa). Although CVAK104 is capable of binding to ATP, sequence analysis ...