The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy

The Role of Apoptosis in Development, Tissue Homeostasis and Malignancy

Death from inside out

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The past five years have witnessed a remarkable development of interest in cell death 'from inside out'. After 30 years of relative obscurity, its quantitative importance in the building and maintenance of normal tissues, the subtle strategies involved in its regulation, and its significance in the pathogenesis of diseases of major social importance are becoming clear. Moreover, because a distinct set of biological events is involved in this death, these events themselves become reason able targets for new pharmacological agents in the treatment of cancer. The articles in this volume summarize...