The Neurovascular Unit and the Role of Astrocytes in the Regulation of Vascular Tone
Jessica A. Filosa
Broschiertes Buch

The Neurovascular Unit and the Role of Astrocytes in the Regulation of Vascular Tone

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Optimal cerebral blood flow is coordinated by functional hyperemia and cerebral autoregulation. These processes ensure that the metabolic demands of the brain are met at all times. Both in vivo and in vitro studies support a role for astrocytes in the regulation of cerebral blood flow. In this we review the cellular mechanisms contributing to astrocyte-mediated vasodilation and vasoconstriction of parenchymal arterioles. Primarily, we discuss how activity-dependent changes in astrocytic Ca2+ contribute to the release of vasoactive signals involved in neurovascular coupling. Following the rise ...