The Local Effect of Calcitonin and Alendronate on Osseous defects

The Local Effect of Calcitonin and Alendronate on Osseous defects

The Effect of Local Administration of Calcitonin and Alendronate on Surgically Created Osseous Defects in Sheep

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Background: Bone regeneration is an important objective in clinical dental practice and has been used for different applications. The anabolic action of antiresorpative agent to promote bone formation and prevent further bone loss is a theoretically attractive approach for restoring bone mass. The ability of Alendronate and salmon Calcitonin to affect bone osteogenesis when employed systematically raises natural questions, if the local influence of both drugs could improve bone regeneration in controlled animal model. Aims of the Study: It was undertaken to evaluate the efficacy of locally app...