The Art of Drug Synthesis
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DISCOVER THE INS ANDOUTS OF DRUG SYNTHESIS, FROM IDENTIFYING A LEAD MOLECULE TO COMMERCIAL PRODUCTION.Learn how chemistry, biology, pharmacokinetics, and a host of other disciplines all play a role in the successful discovery of new drugs and therapeutics. This text features contributions from seventeen leading medicinal and process chemists who show you how it is done. Some of the contributors were instrumental in the discovery of the drugs they review, offering you a unique and invaluable perspective on the complete drug discovery process.The first two chapters of this text introduce the str...
DISCOVER THE INS ANDOUTS OF DRUG SYNTHESIS, FROM IDENTIFYING A LEAD MOLECULE TO COMMERCIAL PRODUCTION.
Learn how chemistry, biology, pharmacokinetics, and a host of other disciplines all play a role in the successful discovery of new drugs and therapeutics. This text features contributions from seventeen leading medicinal and process chemists who show you how it is done. Some of the contributors were instrumental in the discovery of the drugs they review, offering you a unique and invaluable perspective on the complete drug discovery process.
The first two chapters of this text introduce the stringent requirements for a potential therapeutic molecule, approaches in finding molecular structures that 'hit" a biological target, and the many steps needed to go from initial small-scale laboratory synthesis to commercial and the many steps needed to go from initial small-scale laboratory synthesis to commercial production. The remaining fifteen chapters are divided intothree major therapeutic areas:
_ Cancer and infectious Diseases
_ Cardiovascular and Metabolic Diseases
_ Central Nervous System Diseases
These three section collectively cover twenty-one categories of drugs and more than sixty individual drugs, highlighting both medicinal and process synthetic routes. The authors present detailed accounts of the synthesis of such high-profile drugs as Actos(r), Levaquin(r), Avelox(r), Diflucan(r), Tamiflu(r), Zetia(r), Lyrica(r), and Strattera(r). You gain new insight into how a first generational agent is refined and improved by the application of medicinal chemistry for the discovery of second and third generation medicines.
This text is an excellent companion to the bestselling Contemporary Drug Synthesis, covering all new drugs. In addition to serving as a reference for medicinal chemists and pharmacologists, this book is highly recommended as a graduate-level text for medicinal pharmacologists, this book is highly recommended as a graduate-level text for medicinal and pharmaceutical chemistry courses. With its many examples and insights into successful and pharmaceutical chemistry courses. With its many examples and insights into successful syntheses, it enables students to make the bridge from theory to practice.
Learn how chemistry, biology, pharmacokinetics, and a host of other disciplines all play a role in the successful discovery of new drugs and therapeutics. This text features contributions from seventeen leading medicinal and process chemists who show you how it is done. Some of the contributors were instrumental in the discovery of the drugs they review, offering you a unique and invaluable perspective on the complete drug discovery process.
The first two chapters of this text introduce the stringent requirements for a potential therapeutic molecule, approaches in finding molecular structures that 'hit" a biological target, and the many steps needed to go from initial small-scale laboratory synthesis to commercial and the many steps needed to go from initial small-scale laboratory synthesis to commercial production. The remaining fifteen chapters are divided intothree major therapeutic areas:
_ Cancer and infectious Diseases
_ Cardiovascular and Metabolic Diseases
_ Central Nervous System Diseases
These three section collectively cover twenty-one categories of drugs and more than sixty individual drugs, highlighting both medicinal and process synthetic routes. The authors present detailed accounts of the synthesis of such high-profile drugs as Actos(r), Levaquin(r), Avelox(r), Diflucan(r), Tamiflu(r), Zetia(r), Lyrica(r), and Strattera(r). You gain new insight into how a first generational agent is refined and improved by the application of medicinal chemistry for the discovery of second and third generation medicines.
This text is an excellent companion to the bestselling Contemporary Drug Synthesis, covering all new drugs. In addition to serving as a reference for medicinal chemists and pharmacologists, this book is highly recommended as a graduate-level text for medicinal pharmacologists, this book is highly recommended as a graduate-level text for medicinal and pharmaceutical chemistry courses. With its many examples and insights into successful and pharmaceutical chemistry courses. With its many examples and insights into successful syntheses, it enables students to make the bridge from theory to practice.