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Systems Biotechnology of Recombinant Protein Production in Aspergillus niger

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The filamentous fungus Aspergillus niger is an important efficient microbial cell factory for industrial production of enzymes as well as organic acids or antibiotics. In submerged cultivation, A. niger exhibits a rather complex morphology which typically has a strong influence on production performance. Although difficult to control so far, the morphological shape is obviously linked to key production characteristics of fungal cell factories. In this regard, comprehensive approaches, combining systems wide analysis and optimization at the cellular level with process driven engineering of the ...