Synthetic Bioactive Morpholine Based 1,3,4-Oxadiazole Scaffolds
Synthesis of morpholine based 2,5-disubtituted 1,3,4-oxadiazoles
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The presented research work comprises of synthesis, spectral analysis and biological screening of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches were utilized to synthesize poly-functional compounds. The main intention of the present research work was to design and synthesize some new poly-functional compounds having 1,3,4-oxadiazole and acetamide or 1,3,4-oxadiazole, morpholine a...
The presented research work comprises of synthesis, spectral analysis and biological screening of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches were utilized to synthesize poly-functional compounds. The main intention of the present research work was to design and synthesize some new poly-functional compounds having 1,3,4-oxadiazole and acetamide or 1,3,4-oxadiazole, morpholine and sulfide or 1,3,4-oxadiazole, morpholine and acetamide moieties together in one molecule. It was assumed that 2,5-disubstituted-1,3,4-oxadiazol ring along with the potential morpholine moiety and acetamide/sulfide functionality will enhance the activity of the molecule. Keeping in sight the broad diversity of biological activitites, some of the synthesized compounds were checked for their antibacaterial, hemolytic and antifungal screening. Some of compounds were found to be active and showed interesting results as compared to reference standard drugs.
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