Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives

Synthesis of Tri-substituted Imidazo-Thiadiazole Derivatives

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In this study we have synthesized and evaluated some newt tri-substitute imidazo [2, 1-b]- 1,3,4- thiadiazole derivatives comprising coumarin and imidazo [2, 1-b]- 1,3,4- thiadiazole moieties. We have reported a series of imidazo [2, 1-b]- 1,3,4- thiadiazole analogues to target MAPK. The compounds were synthesized by conventional methods and reaction process was monitored by TLC using suitable mobile phase and melting points of synthesized compounds were also determined. Furthermore, synthesized compounds were also characterized and confirmed by IR, 1H-NMR, 13C-NMR and Mass spectra. Two select...