Synthesis of Substituted Butenolides and Related Natural Products
Stereoselective Vinylogous Aldol Reaction of Tetronamides and the Synthesis of Rubrolides and ¿-Substituted Butenolides
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Butenolides are ,beta-unsaturated lactone and are found in many natural and unnatural products with diverse biological properties. Owing to the prevalence of the substituted butenolides, much effort has been directed towards developing efficient methodologies for their synthesis and transformations. Among them, stereoselective access of the Gamma-substituted butenolide derivatives by utilizing the concept of vinylogy, which usually involves the carbon-carbon formation with an appropriate electrophile at the Gamma-position of butenolides, has triggered increasing interest. This thesis presents ...
Butenolides are ,beta-unsaturated lactone and are found in many natural and unnatural products with diverse biological properties. Owing to the prevalence of the substituted butenolides, much effort has been directed towards developing efficient methodologies for their synthesis and transformations. Among them, stereoselective access of the Gamma-substituted butenolide derivatives by utilizing the concept of vinylogy, which usually involves the carbon-carbon formation with an appropriate electrophile at the Gamma-position of butenolides, has triggered increasing interest. This thesis presents an efficient, simple, scalable and direct stereoselective vinylogous aldol reaction of beta-aminosubstituted butenolides (tetronamides) with aldehydes. In addition, this thesis also describes the total syntheses of butenolide core bearing marine natural metabolites, rubrolides by using a highly regioselective late-stage bromination strategy from appropriate intermediates, and apprises a facile reductive dehalogenation of -halo-beta-substituted butenolides.
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