Daniel Globisch
Broschiertes Buch

Synthesis of natural modified nucleosides and their mass spectrometric quantification in cells and tissue

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Natural nucleic acids are the molecules of life. They contain the genetic information of every organism and are involved in many biological processes. Additionally, they were involved for the development of life on earth. All nucleic acids contain natural modified nucleotides, which are incorporated in complex processes and are of tremendous importance for regulation and accuracy of transcription and translation in every organism. Over 120 different modifications were detected in all natural nucleic acids and the number is still increasing. tRNA is the most heavily modified nucleic acid and it...