Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines

Synthesis of Bioactive Heterocycles using 3-Acetyl Quinolines

Chalcones, Pyrazolines, Isoxazolines, Isoxazoles derived from 3-Acetyl Quinolines: Antimicrobial and Cytotoxcity Studies

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Quinoline heterocycles found to have diverse biological activities and 3-functionalised quinolines are important intermediates for the synthesis of various quinoline derivatives. 3-acetyl-4-hydroxy-quinolin-2(1H)-one and 6-chloro-3-acetyl-4-phenyl-2-methyl quinoline were chosen as intermediates for the synthesis of some novel quinoline derivatives. In particular, only a few methods are available for the synthesis of 3-acetyl-4-hydroxy-quinolin-2(1H)-one, which involve either two step or multistep reaction protocols. In the present work, a rapid, efficient and one pot procedure for the synthesi...