Synthesis of 4¿-substituted 2¿, 3¿-dideoxynucleoside analogues
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Most of biologically active compounds are chiral. The asymmetric synthesis is an important tool to prepare the compounds in order to develop modern drugs. The importance of stereoselective processes in the synthesis of pharmaceutical compounds has been recognized only recently. Thus, pharmaceutical industry needs efficient processes - it means that the most important parameters of the asymmetric synthesis to be taken into account are stereoselectivity of the conversion, yield of the product, price of reagents and simplicity of procedure. In the literature there are many examples of the asymmet...
Most of biologically active compounds are chiral. The asymmetric synthesis is an important tool to prepare the compounds in order to develop modern drugs. The importance of stereoselective processes in the synthesis of pharmaceutical compounds has been recognized only recently. Thus, pharmaceutical industry needs efficient processes - it means that the most important parameters of the asymmetric synthesis to be taken into account are stereoselectivity of the conversion, yield of the product, price of reagents and simplicity of procedure. In the literature there are many examples of the asymmetric synthesis of different pharmaceutical compounds, however, the number of good industrial asymmetric processes is limited.
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