Synthesis and Biological Evaluation of N and S Based Heterocycles
New Synthetic Approaches to Nitrogen and Sulfur Based Heterocycles and Biological Assessment for Selected Analogs
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Nitrogen and sulfur heterocycles are recognized as "privileged medicinal scaffolds" because these compounds are found in a wide variety of bioactive natural products and pharmaceuticals. Among them, azoles (1,2 and 1,3-azoles) have been considered as an 'important structural motif' in a huge number of natural products and also in medicinally valuable compounds. Because of their broad based utility, efforts to develop green and sustainable synthetic methodologies for the synthesis of 1,2 and 1,3-azoles are on the ever-increasing trend in synthetic organic chemistry. In the present study, attemp...
Nitrogen and sulfur heterocycles are recognized as "privileged medicinal scaffolds" because these compounds are found in a wide variety of bioactive natural products and pharmaceuticals. Among them, azoles (1,2 and 1,3-azoles) have been considered as an 'important structural motif' in a huge number of natural products and also in medicinally valuable compounds. Because of their broad based utility, efforts to develop green and sustainable synthetic methodologies for the synthesis of 1,2 and 1,3-azoles are on the ever-increasing trend in synthetic organic chemistry. In the present study, attempts have been made to develop new synthetic routes for the synthesis of benzo-fused 1,2-azoles (indazoles) and 1,3-azoles (benzimidazoles) and nitrogen and sulfur containing 1,3- azoles like thiazoles (i.e. 2-aminothiazoles and hydrazinyl-thiazoles). Further, biological activities (antioxidant, antimicrobial and anti-cancer) of the synthesized hydrazinyl-thiazole compounds have been investigated.
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