Sustained Release Matrix Tablet of Theophylline & Etophylline
Versandkostenfrei!
Versandfertig in 6-10 Tagen
26,99 €
inkl. MwSt.
PAYBACK Punkte
13 °P sammeln!
The present investigation an effort has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient fulfillment, by developing SR matrix tablets of theophylline and etophylline by using wet granulation technique incorporating different polymers combinations and fillers. SR tablets of various combinations were prepared by using hydrophilic polymer: HPMC, sodium alginate and starch as fillers. The drug excipients mixtures were subjected to preformulation studies. The formulated tablets (F1-F10) were evaluated for different physicochemical properties and com...
The present investigation an effort has been made to increase therapeutic efficacy, reduce frequency of administration and improve patient fulfillment, by developing SR matrix tablets of theophylline and etophylline by using wet granulation technique incorporating different polymers combinations and fillers. SR tablets of various combinations were prepared by using hydrophilic polymer: HPMC, sodium alginate and starch as fillers. The drug excipients mixtures were subjected to preformulation studies. The formulated tablets (F1-F10) were evaluated for different physicochemical properties and comply with the official standards. FTIR studies shown there was no interaction between drug and polymers. The optimized formulations (F3) were subjected to stability studies and shown there were no significant changes in drug content, physicochemical parameters and release pattern. Assay of the drug and formulation was carried out by using RP-HPLC method. The in vitro release studies exhibits the release up to 82%, over a prolonged period of time which confirms the extended release profile of formulation (F3) after 6 hrs as compared to marketed formulation.
Andere Kunden interessierten sich für
