Suppressing the Mind
Anesthetic Modulation of Memory and Consciousness
Herausgegeben: Hudetz, Anthony; Pearce, Robert
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This book will present original results as well opinionated overviews of the current state of knowledge of the problem of anesthesia-induced unconsciousness and amnesia. It will present evidence from molecular to system levels and lead to an integrative theory of anesthetic-induced unconsciousness and amnesia. The hypothesized mechanism underlying anesthetic action will be explored as a demonstration of "bridging the gap" between bench and clinical research. It will synthesize information spanning a number of levels from molecular integrative that has begun to reveal answers to the longstanding mystery of anesthesia.
Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation ofmemory. Seven of the chapters are based on material presented at these symposia - appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of "anesthesia awareness," a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.
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