Sulfonamide Based Polymeric Systems for Cancer Tumors
Vijay Sethuraman
Broschiertes Buch

Sulfonamide Based Polymeric Systems for Cancer Tumors

Design and study of sulfonamide polymer based pH sensitive micelles and polyplexes for targeting acidic solid tumors

Versandkostenfrei!
Versandfertig in 6-10 Tagen
44,99 €
inkl. MwSt.
PAYBACK Punkte
22 °P sammeln!
This monograph focuses on the design and study of innovative polymeric drug delivery systems for acidic solid cancer tumors. A sulfonamide-based pH-sensitive polymer was developed to mask conventional delivery systems such as gene carrier and polymeric micelles, during systemic circulation and unmask them at the acidic tumor. First a pH-sensitive polymer (PSD-b-PEG) was evaluated in a gene delivery model. Plasmid DNA was complexed with PEI, this further complexed with PSD-b-PEG to construct a nanoparticle. The nanoparticles showed low cytotoxicity (20%) and low transfection at pH 7.4 due to sh...