Study of Akt1 Gene Intronic Variant in Chronic Myeloid Leukemia

Study of Akt1 Gene Intronic Variant in Chronic Myeloid Leukemia

Akt1 Gene

Versandkostenfrei!
Versandfertig in 6-10 Tagen
27,99 €
inkl. MwSt.
PAYBACK Punkte
14 °P sammeln!
Chronic myelogenous leukemia (CML) is a hematological malignancy characterized by the translocation of 9th and 22nd chromosome. It results in the formation of a fusion gene, Bcr-Abl with increased tyrosine kinase activity which interferes with cellular proliferation, cell death and activates various downstream pathways. Despite the presence of targeted drug, Imatinib mesylate, many patients tend to develop resistance, which could be because of deregulation of genes involved in various pathways. Akt is one of the most important gene being activated by Bcr-Abl. This gene is known to regulate mul...