Studies on the Synthesis of Fused Primidine Derivatives
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INTRODUCTION Pyrimidine Pyrimidine (1) is the trivial name for 1,3-diazine: two meta oriental CH units in benzene have been replaced by nitrogen atom. Pyrimidine has one axis of symmetry about the C2-C5 axis, it has three different pairs of bond lengths and four different bond angles. Accordingly in 1H and 13C-NMR spectra the 1H and 13C nuclei are found at three different chemical shifts. Biological activity of pyrimidines: Pyrimidine derivatives and heterocyclic annelated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities and therapeuti...
INTRODUCTION Pyrimidine Pyrimidine (1) is the trivial name for 1,3-diazine: two meta oriental CH units in benzene have been replaced by nitrogen atom. Pyrimidine has one axis of symmetry about the C2-C5 axis, it has three different pairs of bond lengths and four different bond angles. Accordingly in 1H and 13C-NMR spectra the 1H and 13C nuclei are found at three different chemical shifts. Biological activity of pyrimidines: Pyrimidine derivatives and heterocyclic annelated pyrimidines continue to attract great interest due to the wide variety of interesting biological activities and therapeutic applications [Segal et al., 1962][Cumming et al., 2004] such as anticonvulsant [Tripathi et al., 1981], analgesic [Pemmsin et al., 1988], antihypertensive [Cammito et al., 1990], antipyretic [Smith et al., 1964], antiviral [Balzarini et al., 2002], anti-inflammatory drugs [Nega et al., 1990], bactericidal [Mastafanova et al., 1982], fungicidal [Zhikhareva et al., 1976]. As well as, they are used in agriculture as pesticides [Tetsuo et al., 1987] and plant growth regulators [Shishoo and Jain, 1992].
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