Studies of Interactions Between Myeloma Cells and Osteoblasts
Abdullah Karadag
Broschiertes Buch

Studies of Interactions Between Myeloma Cells and Osteoblasts

In Vitro

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Multiple myeloma is a malignant lymphoproliferative disorder of differentiated B cells, characterised by the accumulation of plasma cells in the bone marrow where they interact with bone marrow cells disrupting normal haemopoiesis and causing thrombocytopenia, anaemia, bone destruction and hypercalcaemia. Multiple myeloma is associated with the development of osteolytic bone disease, characterised by the presence of bone lesions, pathological fractures, osteoporosis and hypercalcaemia. The mechanisms by which osteolytic bone lesions occur in multiple myeloma remain unclear. Histomorphometric s...