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A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in drug development for cancer and neurodegenerative diseases.…mehr

Produktbeschreibung
A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in drug development for cancer and neurodegenerative diseases.
Autorenporträt
Peter Tompa is Group Leader in the Laboratory of Intrinsically Disordered Proteins, Institute of Enzymology, Biological Research Center at the Hungarian Academy of Sciences in Budapest.