Structure and Function of Intrinsically Disordered Proteins
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A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in dru...
A detailed investigation into intrinsically disordered proteins (IDP), this seminal work illustrates how IDPs defy the structure-function paradigm and play important regulatory and signaling roles. Introducing basic terms and fundamental principals of protein science, the author presents a unified theory of ordered and disordered proteins and outlines new applications for traditional biophysical and bioinformatic techniques, such as x-ray crystallography and NMR. The book reviews the structure, function, and evolution of IDPs and considers biomedical implications as well as applications in drug development for cancer and neurodegenerative diseases.
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