Structural Analysis of the 50S Ribosomal Stalk
Mihaela tefania Diaconu
Broschiertes Buch

Structural Analysis of the 50S Ribosomal Stalk

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This work proposes a structural model of the 50S ribosomal stalk, which explains its critical role in the process of protein biosynthesis occurring in a living cell. Thus, it was envisioned that the stalk is organized into three structural and functional elements, which are connected by flexible regions: (i) the stalk base, formed by the L10/L11 rRNA binding region, L11 and the L10 NTD, serving as attachment site for peripheral components; (ii) the C-terminal -helix of L10 in complex with L12 NTD dimers that constitute a movable platform carrying L12 hinges and CTDs; (iii) the highly mobile L1...