Spectrum of Infections in Nephrotic Syndrome of Childhood

Spectrum of Infections in Nephrotic Syndrome of Childhood

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Nephrotic syndrome is the clinical manifestation of glomerular diseases associated with heavy (nephrotic-range) proteinuria. Nephrotic range proteinuria is defined as proteinuria >3.5 g/24 hr or a urine protein : creatinine ratio >2. The triad of clinical findings associated with nephrotic syndrome arising from the large urinary losses of protein are hypoalbuminemia ( 2.5 g/dL), edema, and hyperlipidemia (cholesterol >200 mg/dL). Infection is a major complication in children with Nephrotic syndrome. Patients with relapse will have increased susceptibility to bacterial infection because of urin...