Spectroscopic Studies of Structure and Function of the Light-Gated Cation Channel Channelrhodopsin-2
Melanie Hey
Broschiertes Buch

Spectroscopic Studies of Structure and Function of the Light-Gated Cation Channel Channelrhodopsin-2

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Revealing structural and mechanistic details of Channelrhodopsin-2 (ChR2) is in the focus of current scientific research due to its unique ability to stimulate cell activity by light (optogenetics). Hence, ChR2 is a promising tool to revolutionize medical treatment. The aim of this work was the investigation of the light-activated mechanism of the retinylidene cation channel ChR2 on an atomistic level by means of vibrational spectroscopy. In addition to successful expression and purification of ChR2, resonance Raman and FTIR spectroscopy elucidated the structure of the chromophore binding pock...