Vishal Sanklecha, Vishal Pande

Broschiertes Buch

Solubility Enhancement

Development of Extended Release Matrix Pellets of Water Insoluble Azilsartan Medoxomil using with its Solid Dispersion

Beschreibung

The present study involved the design & development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion. A solid dispersion of azilsartan medoxomil was prepared with a carrier, Affinisol 716G by solvent evaporation technique. Extended release matrix pellets were prepared from Azil SD using a combination of polycarbophil, HPMC K4M, MCC and guar gum. AzilSD & the pellets were evaluated for various physicochemical properties such as solubility, drug loading, drug content, surface morphology & swelling behaviour & analysis carried out using FTIR, DSC & powder XRD. The solubility & dissolution rate of Azil SD was 5.71 and 2.07 times greater, respectively. The optimized batch was selected based on 100% cumulative drug release in 12 hours. Formulation Batch F6 showed 99.19% CDR in 12 hours and drug content 97.89 %. The mechanism of the drug release rate kinetics of Batch F6 followed the Korsmeyer-Peppas. Thus it can be concluded that Affinisol 716G based solid dispersion mechanism, enhances the solubility & dissolution of azilsartain medoxomil by using polycarbophil & HPMC K4M, forming an effective carrierfor developing extended release matrix pellets.

Autor

Vishal Sanklecha completed Post Graduation in Pharmaceutics from Sanjivani College of Pharmaceutical Education & Research, Koprgaon. He currently works at Wockhardt Research Centre in Biotech Formulation & Development Department. He does research in development of Biosimilar Formulation and Enhancement of Solubility of poorly soluble Drug.

Produktdetails

• Verlag: LAP LAMBERT Academic Publishing
• Seitenzahl: 56
• Erscheinungstermin: 20. November 2019
• Englisch
• Abmessung: 220mm x 150mm x 4mm
• Gewicht: 102g
• ISBN-13: 9786200471789
• ISBN-10: 6200471789
• Artikelnr.: 62444583