Santhi Priya Nagam, Siva Krishna Pusuluri, Sreenu Thalla

SOLID DISPERSIONS - AN APPROACH TO ENHANCE THE DISSOLUTION RATE

• Broschiertes Buch

Produktbeschreibung

Oxcarbazepine, 10, 11-dihydro- 10-oxo- 5H-dibenz(b,f)azepine- 5-carboxamide, is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It is also used to treat anxiety and mood disorders, and benign motor tics. Oxcarbazepine is marketed as Trileptal by Novartis and available in some countries as a generic drug. It is a prodrug which is activated to eslicarbazepine in the liver. It is a white or yellowish-white, crystalline powder; almost odourless, with a molecular weight of 252.268 g/mol. Oxcarbazepine is slightly soluble in acetone, chloroform, dichloromethane, and methanol. It is practically insoluble in ethanol, ether, and water. The drug exhibits low bioavailability related to its poor water solubility. Oxcarbazepine is a class II compound, i.e., water-insoluble, lipophilic, and highly permeable according to Biopharmaceutical Classification System. The purpose of this study was to prepare and characterize solid dispersions of the poor watersoluble anticonvulsant with water soluble carrier such as primogel to improve its dissolution properties. The solid dispersions were prepared by co-grinding and solvent evaporation method.

Produktdetails

• Verlag: LAP Lambert Academic Publishing
• Seitenzahl: 72
• Erscheinungstermin: 21. Januar 2025
• Englisch
• Abmessung: 220mm x 150mm x 5mm
• Gewicht: 125g
• ISBN-13: 9786208424442
• ISBN-10: 6208424445
• Artikelnr.: 73359457

Autorenporträt

Mrs Nagam Santhi Priya, Associate Professor, Department of Pharmaceutics, Vignan Pharmacy College (Autonomous), Vadlamudi, Guntur, Andhra Pradesh. Her area of interest in novel drug delivery system, formulations, different dosage regimens.