Simvastatin-Mediated Inhibition Of Prostate Cancer

Simvastatin-Mediated Inhibition Of Prostate Cancer

Molecular Mechanisms Regulating Cellular Functions In-Vitro And Tumor Growth In-Vivo

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Prostate cancer is a leading cause of death in USA. Proper management of disease requires better understanding of mechanisms involved in cancer growth and proliferation. Statins were shown to have beneficial effects in cancers, as proven by the many clinical trials supporting the evidence. Our research studied simvastatin effects and molecular mechanisms affecting prostate cancer in vitro and in vivo. We showed that simvastatin affected proliferation, colony formation and migration, in both androgen-dependent and ¿independent human prostate cancer. In vivo effects were supportive with a reduc...