Simultaneous estimation of antiulcer and antemetic drug by using HPLC

Simultaneous estimation of antiulcer and antemetic drug by using HPLC

Determination of Domperidone and Esomaprazole Magnesium in Tablet Dosage Form by RP-HPLC

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A simple, sensitive and validated HPLC method has been developed to determine esomeprazole and domperidone in tablet dosage form. The chromatographic separation was achieved on a hyperchrome C-18 column column (4.6 x 150mm, 5 particle size) analytical column using a mixture of acetonitrile: Phosphate buffer (pH 5.0) in the ratio of 60:40 (v/v) used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 290 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. Lin...