Sickle Cell Disease: Concerns and Challenges
Gebundenes Buch

Sickle Cell Disease: Concerns and Challenges

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Sickle cell disease (SCD) is a group of inherited blood disorders. Sickle cell anemia (SCA) is the most common form of SCD. It is characterized by an abnormality in hemoglobin found in red blood cells. This results in rigid, sickle-shaped red blood cells. SCA typically develops symptoms like anemia, bacterial infections, stroke, pain, swelling in the hands and feet, etc. The gene defect associated with sickle cell disease is a single nucleotide mutation. Normal red blood cells are elastic thereby allowing cells to deform and pass through capillaries. In SCD, low oxygen tension promotes sicklin...