Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases
Takuya Hidaka
Broschiertes Buch

Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases

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This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequen...