Self Micro-Emulsifying Mouth Dissolving Film
Design, Development and Evaluation
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Self-micro emulsifying mouth dissolving film is a new dosage form, an integration of self-micro emulsifying drug delivery system in a fast mouth dissolving film. Self micro emulsifying drug delivery system(SMEDDS) is an isotropic mixture of oil, surfactant, and co-surfactant. Upon mild agitation followed by dilution in an aqueous medium (gastrointestinal fluids), this system can form fine oil-in-water (o/w) microemulsion. Due to their small droplet size, they can provide a large surface area of absorption and improve the oral bioavailability of drugs more than any other drug delivery system. T...
Self-micro emulsifying mouth dissolving film is a new dosage form, an integration of self-micro emulsifying drug delivery system in a fast mouth dissolving film. Self micro emulsifying drug delivery system(SMEDDS) is an isotropic mixture of oil, surfactant, and co-surfactant. Upon mild agitation followed by dilution in an aqueous medium (gastrointestinal fluids), this system can form fine oil-in-water (o/w) microemulsion. Due to their small droplet size, they can provide a large surface area of absorption and improve the oral bioavailability of drugs more than any other drug delivery system. The composition of SMEDDS improves the solubility of poorly water-soluble drugs in an aqueous medium. Fast mouth dissolving films are complex polymeric matrices that can disintegrate/dissolve in the mouth within a short time. After dissolution, the drug gets available in the oral cavity for buccal mucosa absorption and reaches the systemic circulation without undergoing presystemic metabolismof the drug. These also have some advantages over other oral formulations including convenience to transport and store.
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