Self Micro Emulsifying Drug Delivery System
Formulation & Evaluation of Supersaturable Dry Microemulsion for the Enhancement of Dissolution
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Supersaturable SMEDDS appeared to be an interesting approach to alleviate problems associated with oral delivery of Nebivolol. This can be achieved by using NEB-SMEDDS having the formula as Castor oil (30 %,v/v), Tween-80 (35 %,v/v), PEG-400 (35 %,v/v) and HPMC(5%)was successfully optimized to achieve higher release as well as bioavailability of NEB in F8 formulation of SMEDDS in comparison to plain drug suspension. Stability of the formulation was confirmed by thermodynamic stability study and long term stability study. The release and bioavailability from F8 SMEDDS was increased due to prese...
Supersaturable SMEDDS appeared to be an interesting approach to alleviate problems associated with oral delivery of Nebivolol. This can be achieved by using NEB-SMEDDS having the formula as Castor oil (30 %,v/v), Tween-80 (35 %,v/v), PEG-400 (35 %,v/v) and HPMC(5%)was successfully optimized to achieve higher release as well as bioavailability of NEB in F8 formulation of SMEDDS in comparison to plain drug suspension. Stability of the formulation was confirmed by thermodynamic stability study and long term stability study. The release and bioavailability from F8 SMEDDS was increased due to presence of drugs in lipidic micro form as well as in dissolved state.In this book, the solid SMEDDS of NEB was prepared by adsorption method, using Aerosil-200 as adsorbent. The solid SMEDDS consisted of well-separated particles with smooth surface and preserved the self-emulsification performance of the liquid SMEDDS. The DSC study shows that NEB S-SMEDDS may be in the dissolved state. In-vitrodissolution test showed that the solid SMEDDS had a faster in vitro release rate than the plain drug suspension NEB.
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